A pathological spine fracture is a break in the vertebrae that is caused by an underlying disease. These are frequently caused by tumors that either originate in the vertebrae or result from a cancer that has been spread throughout the body. Symptoms can consist of pain in the back, legs, and arms and neurological impairment such as numbness and/or weakness in the arms or legs. Non-operative treatments are recommended for less severe pathological fractures. These include taking pain medications, wearing a brace, and limiting physical activity. Surgery may be considered if the spine appears to be unstable or if there is significant compression of the neural elements.